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Immunotherapy

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15.10.2021
20:05 IsraelNationalNews.Com Making cancer immunotherapy more accessible

Off-the-shelf therapies to be developed for entire groups of patients.

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14.10.2021
18:11 ScienceDaily.com How immunotherapy changes tumors

Engineers have used a non-invasive optical probe to understand the complex changes in tumors after immunotherapy, a treatment that harnesses the immune system to fight cancer. Their method combines detailed mapping of the biochemical composition of tumors with machine learning.

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06:44 News-Medical.Net Non-invasive optical probe reveals the complex changes in tumors after immunotherapy

Johns Hopkins University engineers are the first to use a non-invasive optical probe to understand the complex changes in tumors after immunotherapy, a treatment that harnesses the immune system to fight cancer.

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12.10.2021
20:47 WhatReallyHappened.com The drugs that can make 'terminal' cancer patients' tumours VANISH: New immunotherapy treatment can destroy growths and may help people live longer, study finds

A new cancer treatment can destroy tumors in patients who have been diagnosed as terminally ill, a study has found.

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17:21 ScienceDaily.com New avenues for the optimzation of dendritic cell-based cancer immunotherapies

A recent study reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances antitumor responses.

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04:59 News-Medical.Net Research provides insights on colorectal cancers’ immunotherapy resistance

Immune checkpoint inhibitors, which unleash the immune response against tumor cells, have revolutionized cancer treatment; however, the medications aren't effective in a large number of patients, including those with colorectal cancer.

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08.10.2021
17:03 ScienceDaily.com Gel enhances CAR-T immunotherapy benefits in brains surgically treated for glioblastoma

Researchers report that pairing a newly developed fibrin gel with CAR-T immunotherapy that was delivered to post-surgical mouse brains with glioblastoma improved the immunotherapy's effectiveness. The gel aided CAR-T cell distribution in the brain by acclimating the T cells to the post-surgical wound environment while also stopping the tumor from recurring.

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05:17 News-Medical.Net Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

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07.10.2021
16:12 FierceBiotech.com Yale spinout shows how targeting cancer cells' acidic environment might enhance immunotherapy

Yale spinout shows how targeting cancer cells' acidic environment might enhance immunotherapy aliu Wed, 10/06/2021 - 07:38

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08:35 News-Medical.Net Newly developed gel helps improve the effectiveness of immunotherapy for glioblastoma

Pairing a newly developed gel with immunotherapy that was delivered to post-surgical mouse brains with glioblastoma, a highly malignant and deadly cancer, improved the immunotherapy's effectiveness, report researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues. The findings appeared on Oct. 6, 2021, in Science Advances.

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02:43 News-Medical.Net Black NSCLC patients receiving immunotherapy have lower risk of death than white counterparts

Non-Hispanic Black patients with non-small cell lung cancer (NSCLC) who were treated with immunotherapy had a lower risk of death than their non-Hispanic white counterparts treated with immunotherapy, according to results presented at the virtual 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held October 6-8, 2021.

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06.10.2021
18:41 Nature.Com Metabolic modulation of tumours with engineered bacteria for immunotherapy

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01.10.2021
17:55 AzoNano.com Scientists Develop New Nanoparticle for Intravenous Cancer Immunotherapy

Cancer immunotherapy aims to change “cold” tumors into “hot” tumors – those that react to immunotherapy – by stimulating and enlisting the immune system of the...

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11:07 Technology.org New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn “cold” tumors into “hot” tumors––those that respond to immunotherapy––by awakening and enlisting the

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10:12 Technology.org New nano particles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor

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05:20 News-Medical.Net Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

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30.09.2021
22:46 Nanowerk.com New nanoparticle developed for intravenous cancer immunotherapy

Researchers demonstrated the tumor-fighting effects of CMP nanoparticle system in various tumors, including colon carcinoma, melanoma, and head and neck cancer.

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20:52 ScienceDaily.com New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn 'cold' tumors into 'hot' tumors -- those that respond to immunotherapy -- by awakening and enlisting the body's own immune system.

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19:39 Phys.org New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

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12:00 Technology.org Glioma subtype may hold the secret to the success of immunotherapies

A common mutation in gliomas sensitizes them to immunotherapy, a finding which researchers believe could have broader therapeutic

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29.09.2021
23:46 ScienceDaily.com Glioma subtype may hold the secret to the success of immunotherapies

A common mutation in gliomas sensitizes them to immunotherapy, a finding which researchers believe could have broader therapeutic implications for all glioma patients.

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19:22 Entrepreneur.com Combining an HIV vaccine with immunotherapy may reduce the need for daily medication

People with HIV need to take daily medication to keep the virus at bay. A study has found that a new treatment combination could boost immunity and co...

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15:57 Phys.org New nanoinducer of interferons found for cancer immunotherapy

Cancer immunotherapy such as immune checkpoint blockade (ICB) is a revolutionary treatment against tumors by re-enforcing immune surveillance and even inducing long-term disease control.

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09:02 News-Medical.Net Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

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27.09.2021
09:20 News-Medical.Net B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients.

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22.09.2021
08:52 News-Medical.Net Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

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20.09.2021
18:37 AzoNano.com New Lipid Nanoparticles Could Help Overcome Resistance to Anti-Tumor Immunotherapy

Researchers from Hokkaido University and their collaborators in Japan have identified a strategy to help certain patients overcome resistance to immunotherapy treatment for cancer. The approach has...

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08:31 News-Medical.Net Immunotherapy treatment may be appropriate for patients with earlier stages of melanoma

An immunotherapy called pembrolizumab reduced cancer recurrence after surgery in patients with stage IIb and IIc melanoma, according to the results of an international, randomized phase III clinical trial led by UPMC Hillman Cancer Center.

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19.09.2021
23:00 News-Medical.Net Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

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17.09.2021
16:39 News-Medical.Net Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

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14:20 Nanowerk.com New nanoparticles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

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11:52 Technology.org New nano particles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor

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15.09.2021
13:25 FightAging.Org Immunotherapy Targeting Tau Aggregation Slows Cognitive Decline in Later Stages of Alzheimer's Disease

Immunotherapies that have successfully targeted amyloid-β have failed to help Alzheimer's patients to any meaningful degree. This may be because amyloid-β is only relevant in the earliest stages of the condition, or because the most visible amyloid-β aggregation outside cells is a side-effect of neurodegeneration rather than a core disease process. The research community has in recent years turned increasing attention to immunotherapies that target tau aggregation, characteristic of the later stages of Alzheimer's disease. There appears to be a bidirectional relationship between neuroinflammation and the accumulation of toxic, altered forms of tau. As noted here, targeting tau in human trials is starting to produce data that is more suggestive of patient benefits. Still, this is a painfully incremental process, and the results are still […]

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14.09.2021
11:43 Technology.org Scientists developed a tool to tell which cancer patients will respond to immunotherapy

Immunotherapy is a relatively young approach to cancer treatment. It basically empowers the body’s own immune system to

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07:33 News-Medical.Net Synthetic molecular code shows promise towards improving immunotherapy response of cancer patients

A synthetic molecular code shows promise towards improving the response of some cancer patients to immunotherapy treatments.

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03:19 News-Medical.Net Analysis finds untapped potential for immunotherapy in older cancer patients

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

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12.09.2021
21:46 News-Medical.Net High-dose chemotherapy followed by immunotherapy benefits patients with acute myeloid leukemia

A clinical trial conducted at UNC Lineberger Comprehensive Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center found that high-dose cytarabine followed by subsequent immunotherapy treatment with pembrolizumab benefited patients with resistant or relapsed acute myeloid leukemia (AML), a highly aggressive cancer.

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09.09.2021
09:03 News-Medical.Net Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome-;the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts-;can impact us in a variety of different ways, from our metabolism to our mood.

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02:14 News-Medical.Net New tool can rapidly quantify T cell fraction and predict immunotherapy response

Scientists at UCL and the Francis Crick Institute, London, have developed a new tool, which can rapidly estimate the number of T cells (immune cells) in a cancerous tumor; with T cell abundance helping predict a patient's response to immunotherapy, researchers are hopeful this could enable more targeted and effective cancer therapies.

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08.09.2021
01:40 News-Medical.Net Cancer immunotherapies could benefit older patients as much as younger people

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

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07.09.2021
16:39 StemCellsPortal.coml Stem-like T cells could aid immunotherapy in cancer treatment

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03.09.2021
22:48 ScienceDaily.com Stem-like T cells could aid immunotherapy in cancer treatment

Researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters.

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20:37 ScienceDaily.com Many with food allergies don’t know about oral immunotherapy treatment option

A study of a geographically, clinically, and socioeconomically diverse, nationally-representative sample of US households -- including both adult patients and caregivers of children with food allergy -- found that 72 percent did not know what oral immunotherapy (OIT) was prior to the survey. Researchers also discovered that current OIT awareness is disproportionately elevated among wealthier, more highly educated respondents, which underscores the need for more equitable outreach efforts and greater access to these therapies for all patients with food allergies.

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03:39 News-Medical.Net Simple blood test enables early detection of immunotherapy-triggered encephalitis

Immunotherapy is very effective for many cancers, but the treatment can also cause autoimmune side effects. Encephalitis is one of the most serious and difficult-to-diagnose side effects of immunotherapy.

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02.09.2021
17:07 ScienceDaily.com Immunotherapy for HPV+ head and neck cancer: Awakening the force within

The immune cells that are the major targets of immune checkpoint inhibitors (stem-like PD-1+ CD8 T cells) are present in HPV+ tumors from head and neck cancer patients, according to a new study. The results have implications for how immunotherapy could be used to treat this type of head and neck cancer.

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01.09.2021
07:50 News-Medical.Net New review looks at the bottlenecks and breakthroughs in cancer immunotherapy

After over a century of development, cancer immunotherapy (CIT) has risen to become a promising approach for treating cancer. Unlike conventional methods that try to kill cancer cells directly, CIT involves modifying or stimulating the immune system's natural ability to fight the disease. So far, various CIT treatments have shown remarkable results in terms of survival rates, and many new and combination strategies are currently under study.

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30.08.2021
23:14 Technology.org Researchers develop and trial new class of immunotherapy drug to fight cancer

Immunotherapy works by stimulating the body’s natural defence system to attack cancer. Currently, all antibody drugs used for

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26.08.2021
17:13 ScienceDaily.com Biomarker may help predict benefits of immunotherapy

A group of researchers reported that a specific pattern, or 'signature,' of markers on immune cells in the blood is a likely biomarker of response to checkpoint immunotherapy. Within this immune signature, a molecule LAG-3 provided key information identifying patients with poorer outcomes.

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04:25 News-Medical.Net MSK researchers identify potential biomarker of response to checkpoint immunotherapy

In recent years, immune-based treatments for cancer have buoyed the hopes of doctors and patients alike. Drugs called immune checkpoint inhibitors have provided lifesaving benefits to a growing list of people with several types of cancer, including melanoma, lung cancer, bladder cancer, and many more.

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22.08.2021
17:40 ScienceDaily.com PULSAR-integrated radiotherapy with immunotherapy for improved tumor control

Cancer physicians are pioneering a new PULSAR radiation-therapy strategy that improves tumor control compared with traditional daily therapy.

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21.08.2021
05:46 News-Medical.Net New prediction model can identify NSCLC patients who are not likely to respond to immunotherapy

Immunotherapy agents that inhibit the molecules PD1, PD-L1 or CTLA-4 have become widely used in clinical practice to treat non-small cell lung cancer, or NSCLC.

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18.08.2021
22:43 ScienceDaily.com Inhibitor drug entinostat ‘primes’ the body to better respond to anti-cancer treatment with immunotherapy

Combining a histone deacetylase inhibitor drug with immunotherapy agents has been deemed safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial.

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15:00 WhatReallyHappened.com Researchers launch clinical trial to see if aspirin could treat aggressive breast cancer when paired with immunotherapy

Aspirin is being trialled as part of a potential new treatment for an aggressive form of breast cancer. Researchers hope the cheap and widely available drug could work well when combined with immunotherapy for patients with triple negative breast cancer.

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17.08.2021
20:19 News-Medical.Net Dysregulation of innate lymphoid cells drives colon cancer progression and immunotherapy resistance

An immune cell subset called innate lymphoid cells (ILC3s) protects against colorectal cancer, in part by helping to maintain a healthy dialogue between the immune system and gut microbes, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. The finding opens the door to new strategies for treating this type of cancer.

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03:11 News-Medical.Net Experimental drug and immunotherapy combination shows promise in bladder cancer study

A new study in mice found that adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission.

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02:38 News-Medical.Net Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

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16.08.2021
22:33 FightAging.Org Continued Discussion of the Ability of Immunotherapies to Remove Amyloid-β from the Brain

Is amyloid-β aggregation an important cause of Alzheimer's disease, or is it a side-effect of other, more important mechanisms? Near all age-related conditions are complex, with multiple interacting mechanisms involved. Absent a way to remove just one of those mechanisms, it is quite hard to say which are more or less important. In Alzheimer's disease this is made worse by the fact that the animal models are very artificial: few shorter lived mammals naturally develop anything even remotely resembling the biochemistry of Alzheimer's disease. Thus whether or not a treatment produces benefits in animal models is a poor indicator of whether or not it will produce benefits in humans. The quality of the model rests on unproven assumptions about the relevance of specific mechanisms to […]

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20:53 ScienceDaily.com Experimental drug that boosts immunotherapy shows promise in bladder cancer study

Researchers have found adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission in mice. This approach shows such promise that it's already being tested in an ongoing clinical trial in people with advanced bladder cancer.

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13.08.2021
03:42 News-Medical.Net Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

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12.08.2021
06:12 News-Medical.Net New research offers hope to increase efficacy of immunotherapy for lung cancer

Lung cancer is the leading cause of cancer-related death. Current treatments employ immunotherapy, often in combination with chemotherapy, but benefits to patients remain slight.

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11.08.2021
21:11 FierceBiotech.com Overcoming resistance to cancer immunotherapy by targeting garbage-cleaning cells in tumors

Overcoming resistance to cancer immunotherapy by targeting garbage-cleaning cells in tumors aliu Wed, 08/11/2021 - 12:05

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07.08.2021
04:20 News-Medical.Net New immunotherapy strategy can eliminate pancreatic tumors in mice

Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years.

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06.08.2021
07:34 News-Medical.Net Magnetic nanoparticles could enhance the efficacy of cancer immunotherapy

Boosting the function of natural killer cells with magnetic nanoparticles could make cancer immunotherapy more efficient.

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05.08.2021
20:30 Drugs.com CAR T-Cell Immunotherapy Rids Woman of Tough-to-Treat Lupus

THURSDAY, Aug. 5, 2021 -- In a first, researchers have used genetically tweaked immune system cells to send a woman's severe lupus into remission. The treatment -- called CAR T-cell therapy -- is already approved in the United States for fighting...

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04:49 News-Medical.Net K-State research team aims to improve immunotherapy treatment for cancer patients

Immunotherapy can leverage the body's immune system to fight cancer. While excellent responses have been observed for some patients, a considerably larger number have received little benefit.

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04.08.2021
12:49 Technology.org Researchers uncover way to harness the power of immunotherapy for advanced prostate cancer

It’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer

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03.08.2021
21:43 ScienceDaily.com Researchers uncover a way to harness the power of immunotherapy for advanced prostate cancer

Researchers identified an inhibitor that showed promise against metastatic castration-resistant prostate cancer cells. From there, they continued to untangle the web to discover multiple levels of cellular processes that were preventing the immune system from mounting a response. Break past them with this inhibitor and suddenly what's considered an immune cold tumor turns red hot.

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16:15 Nanowerk.com Nanoparticles could boost cancer immunotherapy

Boosting function of natural killer cells with magnetic nanoparticles could make cancer immunotherapy more efficient, according to a new study.

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15:07 Phys.org Nanoparticles could boost cancer immunotherapy

Boosting function of natural killer cells with magnetic nanoparticles could make cancer immunotherapy more efficient, according to a Northwestern Medicine study published in ACS Nano.

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02.08.2021
20:04 News-Medical.Net Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

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18:04 FierceBiotech.com Unleashing immunotherapy against 'cold' prostate tumors with a new protein target

Unleashing immunotherapy against 'cold' prostate tumors with a new protein target arlene.weintraub Mon, 08/02/2021 - 09:15

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28.07.2021
03:59 News-Medical.Net Biomarker shows potential to predict immunotherapy benefit for breast cancer patients

A biomarker that has proven to be a predictor for response to immunotherapies in melanoma patients also has clinical relevance for breast cancer patients, according to a new study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

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27.07.2021
20:17 ScienceDaily.com Advanced bladder cancers respond to immunotherapy regardless of gene mutation status

Researchers report a study has demonstrated that patients with advanced bladder cancers whose tumors have a mutated FGFR3 gene respond to immunotherapy in a manner that is similar to patients without that mutation. This discovery runs counter to previous research that suggested FGFR3-mutated bladder cancers should not be treated with immunotherapy.

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23.07.2021
03:23 News-Medical.Net Innovative testing platform could enable more precise, personalized immunotherapy

An innovative testing platform that more closely mimics what cancer encounters in the body may allow for more precise, personalized therapies by enabling the rapid study of multiple therapeutic combinations against tumor cells.

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00:51 ScienceDaily.com Personalized immunotherapy: Rapid screening of therapeutic combinations

An innovative testing platform that more closely mimics what cancer encounters in the body may allow for more precise, personalized therapies by enabling the rapid study of multiple therapeutic combinations against tumor cells. The platform uses a three-dimensional environment to more closely mirror a tumor microenvironment.

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20.07.2021
02:45 News-Medical.Net Researchers use appendiceal cancer organoids to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

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19.07.2021
10:47 Technology.org Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice

More doesn’t necessarily mean better — including in cancer treatment. University of Wisconsin–Madison and University of Pittsburgh School

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18.07.2021
09:08 Technology.org Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice

More doesn’t necessarily mean better — including in cancer treatment. University of Wisconsin–Madison and University of Pittsburgh School

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16.07.2021
15:18 Phys.org Acidity-activatable dynamic nanoparticles boost cancer immunotherapy

Immunotherapy has great potential in clinical cancer treatment due to systematic activation of antitumor immunity. However, low immunogenicity, or negative feedback on immunotherapy, greatly hinders the efficacy of currently used cancer immunotherapy.

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09.07.2021
04:17 News-Medical.Net Scientists discover potential marker for the success of immunotherapy in lung cancer patients

Lung cancer has the highest mortality rate of all cancers, and treatment options are extremely limited, especially for patients with oncogenic mutations in the KRAS gene.

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08.07.2021
22:44 ScienceDaily.com Potential marker for success of immunotherapy in the treatment of lung cancer

Lung cancer has the highest mortality rate of all cancers, and treatment options are extremely limited, especially for patients with oncogenic mutations in the KRAS gene. Some patients respond very well to treatment with immune checkpoint inhibitors while it is completely ineffective in others. A research group identified a potential marker for the success of immunotherapy in lung cancer patients and explained the underlying molecular processes.

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07.07.2021
16:18 FierceBiotech.com Improving the response to cancer immunotherapy by reactivating the 'guardian of the genome'

Improving the response to cancer immunotherapy by reactivating the 'guardian of the genome' aliu Wed, 07/07/2021 - 08:03

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06.07.2021
16:19 ScienceDaily.com New cancer findings can give wider access to immunotherapy

Researchers have shown how pharmacological activation of the protein p53 boosts the immune response against tumors. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy.

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12:00 Technology.org New cancer findings can give wider access to immunotherapy

Researchers at Karolinska Institutet publish new findings in the journal Cancer Discovery showing how pharmacological activation of the

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03.07.2021
19:36 ScienceDaily.com Cancer: Immunotherapies without side effects?

Immunotherapy has revolutionized the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious. Scientists have succeeded in establishing the differences between deleterious immune reactions and those targeting tumor cells that are sought after. It appears that while the immune mechanisms are similar, the cell populations involved are different. This work makes it possible to envisage targeted and less dangerous treatments for cancer patients.

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02.07.2021
08:56 News-Medical.Net New PET imaging method tracks immunotherapeutic efficacy in mouse models

Several cancer tumors grow through immunosuppression; that is, they manipulate biological systems in their microenvironments and signal to a specific set of immune cells--those that clear out aberrant cells--to stop acting. It is no wonder that immunotherapy designed to re-establish anti-tumor immunity is rapidly becoming the treatment of choice for these cancers.

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01.07.2021
12:46 Technology.org Cell-based immunotherapy shows promise against melanoma

Immunotherapy based on supercharging the immune system’s natural killer cells has been effective in treating patients with recurrent

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04:38 News-Medical.Net Researchers turn to machine learning to predict when immunotherapy will be effective

When it comes to defense, the body relies on attack thanks to the lymphatic and immune systems. The immune system is like the body's own personal police force as it hunts down and eliminates pathogenic villains.

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30.06.2021
23:18 ScienceDaily.com Machine learning helps in predicting when immunotherapy will be effective

Cancer cells can put the body's immune cells into sleep mode. Immunotherapy can reverse this, but it doesn't work for all patients and all cancer types. Researchers have now developed machine learning models that can predict if someone is likely to respond positively to immunotherapy. In clinical settings, this could pave the way for personalized immunotherapy approaches for patients, as well as guidance on how to best combine immunotherapy with other treatments.

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28.06.2021
13:31 FightAging.Org More Alzheimer's Immunotherapies Improve Biomarkers But Not Patient Outcomes

It took many years of development and trials for immunotherapies targeting amyloid-β aggregation to successfully clear large amounts of these misfolded protein deposits from the brain. Unfortunately, it appears that this has very little effect on patient outcomes in Alzheimer's disease. It is possible that amyloid-β, while damaging, is only relevant in the early stages of the condition, and becomes unimportant once a feedback loop of inflammation and tau aggregation is underway. Equally, amyloid-β aggregation may turn out to be largely a side-effect of persistent infection or metabolic disruption, while the core disease processes are inflammation and vascular dysfunction. Removal of amyloid-β seems like something that should be accomplished in older people, as there is little debate over its ability to cause mild cognitive impairment, […]

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09:10 News-Medical.Net Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

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25.06.2021
03:19 News-Medical.Net Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called "hot" tumors with increased levels of inflammation and the presence of immune cells in and around the tumors.

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03:19 News-Medical.Net New dietary fiber formulation improves the potency of cancer immunotherapies

Many people don't realize that the trillions of bacteria, viruses, and fungi residing within the gastrointestinal tract--collectively called the gut microbiome-- are connected to overall health, and specifically to cancer.

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24.06.2021
03:10 News-Medical.Net Three CU researchers recognized for contributions to immunotherapy in childhood cancer

Three members of the University of Colorado Cancer Center and a longstanding supporter of the campus are part of a group of more than 200 researchers nationwide who were recognized in April with the Team Science Award from the American Association for Cancer Research.

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23.06.2021
06:45 News-Medical.Net Combination of SFRP2 and PD-1 immunotherapy halts aggressive metastatic cancer in preclinical model

In a cancer that has not seen new targeted therapies for over 20 years, MUSC Hollings Cancer Center researcher and oncologist Nancy Klauber-DeMore, M.D., is pioneering new discoveries.

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04:41 News-Medical.Net Cancer immunotherapy may self-limit its efficacy in fighting tumors, study finds

Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor of physiology & biophysics and member of the Institute for Immunology at the University of California, Irvine.

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22.06.2021
23:40 ScienceDaily.com Cancer immunotherapy may self-limit its efficacy

Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study.

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16.06.2021
18:07 Nature.Com ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

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15.06.2021
07:52 News-Medical.Net Weight-based dosing strategy may affect immunotherapy outcomes, shows study

Overweight cancer patients receiving immunotherapy treatments live more than twice as long as lighter patients, but only when dosing is weight-based, according to a study by cancer researchers at UT Southwestern Medical Center.

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11.06.2021
19:10 ScienceDaily.com Astronomy meets pathology to identify predictive biomarkers for cancer immunotherapy

Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.

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