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Immunotherapy

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21.01.2022
16:10 News-Medical.Net New opportunity to induce remission of peanut allergy in young children through oral immunotherapy

A clinical trial funded by the National Institutes of Health has found that giving peanut oral immunotherapy to highly peanut-allergic children ages 1 to 3 years safely desensitized most of them to peanut and induced remission of peanut allergy in one-fifth. The immunotherapy consisted of a daily oral dose of peanut flour for 2.5 years.

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04:29 News-Medical.Net Study shows efficacy, safety of oral immunotherapy in one- to three-year-olds with peanut allergy

The majority of young children treated with peanut immunotherapy achieved desensitization after two and a half years of treatment, and one in five remained in remission 26 weeks after treatment ended, according to a randomized controlled trial published in The Lancet.

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20.01.2022
19:15 ScienceDaily.com Immunotherapy before liver cancer surgery can kill tumor, and likely residual cancer cells

Immunotherapy given before surgery caused liver cancer tumors to die off in one-third of the patients enrolled in a new clinical trial.

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10:38 Technology.org Immunotherapy Combination Shown to Benefit Some Patients with Non-Small Cell Lung Cancer Resistant to Single Immunotherapy

A combination of two drugs that open the floodgates to an immune system attack on cancer curtailed tumor

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18.01.2022
23:20 ScienceDaily.com Biostatisticians launch Cancer-Immu data portal for predicting response to immune checkpoint blockade immunotherapy

A new data portal called Cancer-Immu established by a team of biostatisticians can help cancer clinicians and researchers predict which patients will respond to immune checkpoint inhibitors. With data from 3,652 samples for 16 cancer types, Cancer-Immu is the largest immune checkpoint blockade-related data portal for exploring immunogenomic connections.

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14.01.2022
13:58 Technology.org Cancer Immunotherapy Treatment Developed by Purdue Researchers

Zhong-Yin Zhang of Purdue’s College of Pharmacy and his team of researchers have developed a cancer immunotherapy. The

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10:54 Technology.org Cancer Immunotherapy Treatment Developed by Purdue Researchers

Zhong-Yin Zhang of Purdue’s College of Pharmacy and his team of researchers have developed a cancer immunotherapy. The

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12.01.2022
17:40 Technology.org Method for delivering immune system-stimulating drugs may enhance cancer immunotherapy

The targeted immune system-stimulating approach eliminated tumors in mice, with minimal side effects. Stimulating the body’s immune system

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09.01.2022
10:33 Technology.org Sorting Cancers by ‘Immune Archetypes’ May Offer New Approach For Precision Immunotherapies

Using data from over 300 patient tumors, UC San Francisco researchers have described 12 classes of “immune archetypes”

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07.01.2022
17:47 ScienceDaily.com Sorting cancers by 'immune archetypes' represents potential new approach to developing precision immunotherapies

Using data from over 300 patient tumors, researchers have described 12 classes of 'immune archetypes' to classify cancer tumors. Their findings reveal that cancers from different parts of the body are immunologically similar to one another. These classifications provide unique strategies for enhancing each patient's choice of cancer immunotherapies.

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08:55 News-Medical.Net Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

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27.12.2021
19:18 ScienceDaily.com Dietary fiber improves outcomes for melanoma patients on immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration.

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13:53 Technology.org Dietary fiber improves outcomes for melanoma patients on immunotherapy, research shows

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to

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26.12.2021
18:52 News-Medical.Net High-fiber diet helps melanoma patients to respond better to immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration that includes the Oregon State University College of Pharmacy.

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16:21 News-Medical.Net High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Dietary fiber and probiotics impact gut bacteria and immunotherapy responses in melanoma patients, a new study in patients shows.

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24.12.2021
02:24 News-Medical.Net Fiber-rich diet may help some melanoma patients to respond to immunotherapy

A diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome, according to a new study led by researchers at the Center for Cancer Research at the National Cancer Institute, part of the National Institutes of Health, and the University of Texas MD Anderson Cancer Center.

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22.12.2021
19:14 Medscape.Com Early Data Support Neoadjuvant Immunotherapy for NSCLC

A handful of studies on neoadjuvant immunotherapy for lung cancer are nearing completion, Mark Kris reports.

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20.12.2021
00:15 ScienceDaily.com Nanoparticle therapeutic enhances cancer immunotherapy

Researchers have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation of fluid between the chest wall and lungs and is accompanied by malignant cells and/or tumors.

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19.12.2021
02:38 News-Medical.Net Scientists develop new immunotherapy for cancer based on transplant rejection mechanism

A team of scientists at the University of Oslo, Oslo University Hospital Radiumhospitalet and Karolinska Institutet, led by Professor Johanna Olweus, has developed a new type of immunotherapy for cancer.

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16.12.2021
19:06 Phys.org Nanoparticle therapeutic enhances cancer immunotherapy

Researchers at Wake Forest School of Medicine have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation of fluid between the chest wall and lungs and is accompanied by malignant cells and/or tumors.

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15.12.2021
04:56 News-Medical.Net Driving up immunity at tumor site may help enhance immunotherapy treatments

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests.

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14.12.2021
22:43 ScienceDaily.com For children, young adults with recurrent AML, immunotherapy shows promise

Researchers have shown, in a small clinical trial, that an immunotherapy harnessing pre-activated natural killer cells can help some children and young adults with recurrent AML and few other treatment options.

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13.12.2021
15:20 News-Medical.Net MV130 immunotherapy boosts natural and vaccine-induced SARS-CoV-2 immunity in mice

A new mouse study found that intranasal administration of MV130 protected against severe acute respiratory syndrome coronavirus 2.

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12.12.2021
23:49 News-Medical.Net Novel immunotherapy shows promise for children, young adults with recurrent AML

An immunotherapy harnessing the immune system's "natural killer" cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return.

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09.12.2021
17:44 StemCellsPortal.coml Discovery of stem-like t cell in type 1 diabetes holds potential for improving cancer immunotherapy

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11:15 Technology.org New Insights into T-Cell Exhaustion Could Improve Cancer Immunotherapies, Penn Study Finds

Specially engineered immune cells called CAR T cells have proven themselves to be a powerful weapon against blood

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08.12.2021
03:06 News-Medical.Net New approach to enhance the therapeutic efficacy of liver cancer immunotherapy

In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.

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07.12.2021
11:20 Technology.org New immunotherapy for leukemia discovered

Researchers at Karolinska Institutet, University of Oslo and Oslo University Hospital have developed a new kind of immunotherapy

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03.12.2021
17:21 Phys.org Activating immune cells for cancer nano-immunotherapy

With nanotechnology we can understand, mimic, and modulate our immune system. For her Ph.D. research, Annelies Wauters studied how tiny nanocarriers can be used to control the immune system, and target and activate immune cells to fight cancer cells. Wauters defends her thesis on December 3rd.

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02.12.2021
01:46 ScienceDaily.com Discovery of a Stem-like T cell in type 1 diabetes holds potential for improving cancer immunotherapy

As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.

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01.12.2021
16:12 ScienceDaily.com Which glioblastoma patients will respond to immunotherapy?

Scientists have discovered a new biomarker to identify which patients with brain tumors called glioblastomas -- the most common and malignant of primary brain tumors -- might benefit from immunotherapy. The treatment could extend survival for an estimated 20% to 30% of patients. Currently, patients with glioblastoma do not receive this life-prolonging treatment because it has not been fully understood which of them could benefit.

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30.11.2021
23:07 ScienceDaily.com Antihistamines can influence immunotherapy response by enhancing T cell activation

Researchers discovered that antihistamines are associated with improved responses to immunotherapy. Their work revealed a role for the histamine receptor in suppressing T cell activation to block anti-tumor immune responses.

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25.11.2021
05:32 News-Medical.Net Treatment with antihistamines associated with improved responses to immunotherapy

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

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01:58 News-Medical.Net Finding potential biomarkers to predict response to immunotherapy in nonhypermutated cancers

Scientists have discovered a potential biomarker that could more accurately identify which patients with non-hypermutated cancers will respond to specialized immunotherapy drugs called immune checkpoint inhibitors, according to findings published in Science Translational Medicine.

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24.11.2021
17:14 FierceBiotech.com Kymera's first-in-class protein degrader shows potential to boost cancer immunotherapy

Kymera's first-in-class protein degrader shows potential to boost cancer immunotherapy aliu Wed, 11/24/2021 - 07:10

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01:13 ScienceDaily.com Strategy to overcome tumors’ resistance to immunotherapy generates promising clinical trial results

Immune checkpoint inhibitors strengthen the immune response against cancer cells, but the medications are ineffective against certain tumors. Results from a new clinical trial indicate that adding radiation may overcome this resistance to immune checkpoint inhibitors.

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23.11.2021
02:44 News-Medical.Net New score developed to predict outcome in liver cancer patients receiving immunotherapy

There are still no established biomarkers to predict the success of immunotherapy in patients with liver cancer.

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18.11.2021
22:38 FierceBiotech.com Personalized T cells could offer an immunotherapy option to children with brain tumors

Personalized T cells could offer an immunotherapy option to children with brain tumors arlene.weintraub Thu, 11/18/2021 - 13:54

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13.11.2021
07:30 News-Medical.Net Study reveals how certain cells drive immunotherapy resistance in ovarian cancer mouse model

Immune checkpoint inhibitors are a type of cancer treatment that help the immune system's T cells recognize and attack tumors. But these immunotherapy drugs aren't effective against all cancers.

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10.11.2021
03:18 News-Medical.Net Researchers develop model for early prediction of cancer patients' response to immunotherapy

Researchers have developed a model that could predict early on in treatment whether cancer patients will respond to immunotherapy, according to a report published today in eLife.

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02:42 News-Medical.Net Oncologists use immunotherapy at faster rates for trial-ineligible patients, study finds

Cancer patients who are ineligible for clinical trials receive immune checkpoint inhibitors (ICI) at greater rates than patients who are trial eligible despite no survival benefit, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

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09.11.2021
11:41 Technology.org Researchers develop miniature optical fiber treatment device for more effective cancer immunotherapy

Cancer immunotherapy, one of the most important and promising therapies for cancer treatments, is being used by oncologists

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08.11.2021
23:18 ScienceDaily.com Immunotherapy-chemotherapy treatment coupled with in-depth genomic analyses leads to improved survival for patients with mesothelioma

Combining the immunotherapy agent durvalumab with the chemotherapy agents pemetrexed and cisplatin or carboplatin may provide a new treatment option for patients who have inoperable pleural mesothelioma, a cancer of the tissues lining the lungs, according to a phase II clinical trial.

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18:04 FierceBiotech.com Once-failed cancer drug from BioXcel ramps up immunotherapy in mouse models of pancreatic cancer

Once-failed cancer drug from BioXcel ramps up immunotherapy in mouse models of pancreatic cancer arlene.weintraub Mon, 11/08/2021 - 09:33

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04.11.2021
16:36 ScienceDaily.com Experimental drug boosts immunotherapy effectiveness in pancreatic cancer in mice

An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer.

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03.11.2021
22:18 ScienceDaily.com Machine learning model uses clinical and genomic data to predict immunotherapy effectiveness

A new machine learning model accurately predicts whether immune checkpoint blockade (ICB), a growing class of immunotherapy drugs, will be effective in patients diagnosed with a wide variety of cancers. The forecasting tool assesses multiple patient-specific biological and clinical factors to predict the degree of response to immune checkpoint inhibitors and survival outcomes. It markedly outperforms individual biomarkers or other combinations of variables developed so far, according to new findings.

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02:13 News-Medical.Net Immune checkpoint protein may be a promising new target for prostate cancer immunotherapy

The immune checkpoint protein B7-H3 may be a promising new target for immunotherapy in treatment-resistant prostate cancers, according to two new studies led by researchers at the Johns Hopkins Kimmel Cancer Center.

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30.10.2021
15:57 News-Medical.Net Two new studies show how to enhance effectiveness of cancer immunotherapy

Two new studies revealed that anti-PD-1 immunotherapy given before surgery was safe and effective for patients with oral-cavity squamous cell carcinoma (OCSCC) and identified potential molecular biomarkers in the blood and tumors of patients that would show how likely it is that someone would respond to immunotherapy.

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09:48 News-Medical.Net Researchers decipher when and why T cells become non-responsive to immunotherapy

Non-small cell lung cancer is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by reinvigorating a subset of immune cells called T cells, which are "exhausted" and have stopped working.

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29.10.2021
05:20 News-Medical.Net UAB researchers show how to identify non-responding tumors and improve immunotherapy response

Immunotherapy using checkpoint inhibitors can work well to treat cancer, but only a minority of patients respond to therapy.

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28.10.2021
03:20 FierceBiotech.com How targeting a genetic signature of cellular stress may boost cancer immunotherapy

How targeting a genetic signature of cellular stress may boost cancer immunotherapy aliu Wed, 10/27/2021 - 12:51

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26.10.2021
02:20 ScienceDaily.com Immunotherapy may benefit patients with cancer that has spread to tissues around the brain

Immunotherapy may benefit people with leptomeningeal carcinomatosis, a rare but serious complication of cancer that has spread to the brain and/or spinal cord. Treatment with immune checkpoint inhibitors caused notable changes in the characteristics of immune cells within the cerebrospinal fluid of patients. In a phase II clinical trial, treatment extended overall survival in patients compared with historical controls.

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19.10.2021
16:49 Phys.org Novel targeted nano-immunostimulant for cancer immunotherapy developed

Immunotherapy is promising for cancer treatment. The key to improving the therapeutic effect is to drive the patient's own immune system to produce a strong, effective, and enduring tumor-specific immune response. Engineered nanoplatforms show promising potential in strengthening antitumor immune responses.

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18.10.2021
05:34 News-Medical.Net Fibrin immunotherapy may resolve blood clotting induced by SARS-CoV-2

A group of researchers from the United States discovered that the spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can induce the formation of highly inflammatory blood clots amenable to neutralization by a fibrin-targeting monoclonal antibody – opening the door for a completely new strategy to reduce thrombotic inflammation in coronavirus disease 2019 (COVID-19).

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15.10.2021
20:05 IsraelNationalNews.Com Making cancer immunotherapy more accessible

Off-the-shelf therapies to be developed for entire groups of patients.

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14.10.2021
18:11 ScienceDaily.com How immunotherapy changes tumors

Engineers have used a non-invasive optical probe to understand the complex changes in tumors after immunotherapy, a treatment that harnesses the immune system to fight cancer. Their method combines detailed mapping of the biochemical composition of tumors with machine learning.

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06:44 News-Medical.Net Non-invasive optical probe reveals the complex changes in tumors after immunotherapy

Johns Hopkins University engineers are the first to use a non-invasive optical probe to understand the complex changes in tumors after immunotherapy, a treatment that harnesses the immune system to fight cancer.

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12.10.2021
20:47 WhatReallyHappened.com The drugs that can make 'terminal' cancer patients' tumours VANISH: New immunotherapy treatment can destroy growths and may help people live longer, study finds

A new cancer treatment can destroy tumors in patients who have been diagnosed as terminally ill, a study has found.

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17:21 ScienceDaily.com New avenues for the optimzation of dendritic cell-based cancer immunotherapies

A recent study reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances antitumor responses.

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04:59 News-Medical.Net Research provides insights on colorectal cancers’ immunotherapy resistance

Immune checkpoint inhibitors, which unleash the immune response against tumor cells, have revolutionized cancer treatment; however, the medications aren't effective in a large number of patients, including those with colorectal cancer.

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08.10.2021
17:03 ScienceDaily.com Gel enhances CAR-T immunotherapy benefits in brains surgically treated for glioblastoma

Researchers report that pairing a newly developed fibrin gel with CAR-T immunotherapy that was delivered to post-surgical mouse brains with glioblastoma improved the immunotherapy's effectiveness. The gel aided CAR-T cell distribution in the brain by acclimating the T cells to the post-surgical wound environment while also stopping the tumor from recurring.

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05:17 News-Medical.Net Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

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07.10.2021
16:12 FierceBiotech.com Yale spinout shows how targeting cancer cells' acidic environment might enhance immunotherapy

Yale spinout shows how targeting cancer cells' acidic environment might enhance immunotherapy aliu Wed, 10/06/2021 - 07:38

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08:35 News-Medical.Net Newly developed gel helps improve the effectiveness of immunotherapy for glioblastoma

Pairing a newly developed gel with immunotherapy that was delivered to post-surgical mouse brains with glioblastoma, a highly malignant and deadly cancer, improved the immunotherapy's effectiveness, report researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues. The findings appeared on Oct. 6, 2021, in Science Advances.

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02:43 News-Medical.Net Black NSCLC patients receiving immunotherapy have lower risk of death than white counterparts

Non-Hispanic Black patients with non-small cell lung cancer (NSCLC) who were treated with immunotherapy had a lower risk of death than their non-Hispanic white counterparts treated with immunotherapy, according to results presented at the virtual 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held October 6-8, 2021.

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06.10.2021
18:41 Nature.Com Metabolic modulation of tumours with engineered bacteria for immunotherapy

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01.10.2021
17:55 AzoNano.com Scientists Develop New Nanoparticle for Intravenous Cancer Immunotherapy

Cancer immunotherapy aims to change “cold” tumors into “hot” tumors – those that react to immunotherapy – by stimulating and enlisting the immune system of the...

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11:07 Technology.org New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn “cold” tumors into “hot” tumors––those that respond to immunotherapy––by awakening and enlisting the

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10:12 Technology.org New nano particles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor

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05:20 News-Medical.Net Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

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30.09.2021
22:46 Nanowerk.com New nanoparticle developed for intravenous cancer immunotherapy

Researchers demonstrated the tumor-fighting effects of CMP nanoparticle system in various tumors, including colon carcinoma, melanoma, and head and neck cancer.

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20:52 ScienceDaily.com New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn 'cold' tumors into 'hot' tumors -- those that respond to immunotherapy -- by awakening and enlisting the body's own immune system.

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19:39 Phys.org New nanoparticle developed for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

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12:00 Technology.org Glioma subtype may hold the secret to the success of immunotherapies

A common mutation in gliomas sensitizes them to immunotherapy, a finding which researchers believe could have broader therapeutic

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29.09.2021
23:46 ScienceDaily.com Glioma subtype may hold the secret to the success of immunotherapies

A common mutation in gliomas sensitizes them to immunotherapy, a finding which researchers believe could have broader therapeutic implications for all glioma patients.

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19:22 Entrepreneur.com Combining an HIV vaccine with immunotherapy may reduce the need for daily medication

People with HIV need to take daily medication to keep the virus at bay. A study has found that a new treatment combination could boost immunity and co...

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15:57 Phys.org New nanoinducer of interferons found for cancer immunotherapy

Cancer immunotherapy such as immune checkpoint blockade (ICB) is a revolutionary treatment against tumors by re-enforcing immune surveillance and even inducing long-term disease control.

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09:02 News-Medical.Net Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

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27.09.2021
09:20 News-Medical.Net B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients.

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22.09.2021
08:52 News-Medical.Net Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

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20.09.2021
18:37 AzoNano.com New Lipid Nanoparticles Could Help Overcome Resistance to Anti-Tumor Immunotherapy

Researchers from Hokkaido University and their collaborators in Japan have identified a strategy to help certain patients overcome resistance to immunotherapy treatment for cancer. The approach has...

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08:31 News-Medical.Net Immunotherapy treatment may be appropriate for patients with earlier stages of melanoma

An immunotherapy called pembrolizumab reduced cancer recurrence after surgery in patients with stage IIb and IIc melanoma, according to the results of an international, randomized phase III clinical trial led by UPMC Hillman Cancer Center.

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19.09.2021
23:00 News-Medical.Net Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

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17.09.2021
16:39 News-Medical.Net Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

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14:20 Nanowerk.com New nanoparticles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

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11:52 Technology.org New nano particles suppress resistance to cancer immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor

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15.09.2021
13:25 FightAging.Org Immunotherapy Targeting Tau Aggregation Slows Cognitive Decline in Later Stages of Alzheimer's Disease

Immunotherapies that have successfully targeted amyloid-β have failed to help Alzheimer's patients to any meaningful degree. This may be because amyloid-β is only relevant in the earliest stages of the condition, or because the most visible amyloid-β aggregation outside cells is a side-effect of neurodegeneration rather than a core disease process. The research community has in recent years turned increasing attention to immunotherapies that target tau aggregation, characteristic of the later stages of Alzheimer's disease. There appears to be a bidirectional relationship between neuroinflammation and the accumulation of toxic, altered forms of tau. As noted here, targeting tau in human trials is starting to produce data that is more suggestive of patient benefits. Still, this is a painfully incremental process, and the results are still […]

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14.09.2021
11:43 Technology.org Scientists developed a tool to tell which cancer patients will respond to immunotherapy

Immunotherapy is a relatively young approach to cancer treatment. It basically empowers the body’s own immune system to

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07:33 News-Medical.Net Synthetic molecular code shows promise towards improving immunotherapy response of cancer patients

A synthetic molecular code shows promise towards improving the response of some cancer patients to immunotherapy treatments.

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03:19 News-Medical.Net Analysis finds untapped potential for immunotherapy in older cancer patients

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

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12.09.2021
21:46 News-Medical.Net High-dose chemotherapy followed by immunotherapy benefits patients with acute myeloid leukemia

A clinical trial conducted at UNC Lineberger Comprehensive Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center found that high-dose cytarabine followed by subsequent immunotherapy treatment with pembrolizumab benefited patients with resistant or relapsed acute myeloid leukemia (AML), a highly aggressive cancer.

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09.09.2021
09:03 News-Medical.Net Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome-;the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts-;can impact us in a variety of different ways, from our metabolism to our mood.

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02:14 News-Medical.Net New tool can rapidly quantify T cell fraction and predict immunotherapy response

Scientists at UCL and the Francis Crick Institute, London, have developed a new tool, which can rapidly estimate the number of T cells (immune cells) in a cancerous tumor; with T cell abundance helping predict a patient's response to immunotherapy, researchers are hopeful this could enable more targeted and effective cancer therapies.

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08.09.2021
01:40 News-Medical.Net Cancer immunotherapies could benefit older patients as much as younger people

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

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07.09.2021
16:39 StemCellsPortal.coml Stem-like T cells could aid immunotherapy in cancer treatment

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03.09.2021
22:48 ScienceDaily.com Stem-like T cells could aid immunotherapy in cancer treatment

Researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters.

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20:37 ScienceDaily.com Many with food allergies don’t know about oral immunotherapy treatment option

A study of a geographically, clinically, and socioeconomically diverse, nationally-representative sample of US households -- including both adult patients and caregivers of children with food allergy -- found that 72 percent did not know what oral immunotherapy (OIT) was prior to the survey. Researchers also discovered that current OIT awareness is disproportionately elevated among wealthier, more highly educated respondents, which underscores the need for more equitable outreach efforts and greater access to these therapies for all patients with food allergies.

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03:39 News-Medical.Net Simple blood test enables early detection of immunotherapy-triggered encephalitis

Immunotherapy is very effective for many cancers, but the treatment can also cause autoimmune side effects. Encephalitis is one of the most serious and difficult-to-diagnose side effects of immunotherapy.

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02.09.2021
17:07 ScienceDaily.com Immunotherapy for HPV+ head and neck cancer: Awakening the force within

The immune cells that are the major targets of immune checkpoint inhibitors (stem-like PD-1+ CD8 T cells) are present in HPV+ tumors from head and neck cancer patients, according to a new study. The results have implications for how immunotherapy could be used to treat this type of head and neck cancer.

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01.09.2021
07:50 News-Medical.Net New review looks at the bottlenecks and breakthroughs in cancer immunotherapy

After over a century of development, cancer immunotherapy (CIT) has risen to become a promising approach for treating cancer. Unlike conventional methods that try to kill cancer cells directly, CIT involves modifying or stimulating the immune system's natural ability to fight the disease. So far, various CIT treatments have shown remarkable results in terms of survival rates, and many new and combination strategies are currently under study.

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